
Biju Mathew MD
Founder, Board-Certified Internal Medicine Physician
Med Spa and Weight Loss Clinic in Frisco, TX
Welcome to Millennia Wellness MD
At Millennia Wellness MD, we combine advanced aesthetic treatments with personalized wellness care to help you look and feel your best. Our med spa in Frisco, TX offers a luxurious, patient-focused experience featuring medical weight loss, hormone therapy, skin rejuvenation, and cutting-edge aesthetic services under the expert guidance of Dr. Biju Mathew.

About Us
Meet your med spa & wellness team
Millennia Wellness MD is a premier wellness med spa and weight loss clinic in Frisco, TX led by Dr. Biju Mathew, a board-certified internal medicine physician with over 10 years of experience. We specialize in personalized weight loss programs using advanced therapies, including GLP-1 for medical weight loss and lipotropic injections.
Our comprehensive approach ensures each patient receives tailored nutrition coaching and monthly follow-up appointments for sustained results. Our services extend beyond weight loss to include hormone therapy, wellness services, and advanced aesthetic treatments like dermal fillers in Frisco.
We take a multidimensional view of health, focusing on prevention and lifestyle modifications to help our patients live healthier, more fulfilled lives. Dr. Mathew's expertise in preventative and lifestyle medicine ensures every patient receives the highest standard of care.
Great practice! Dr. Mathew takes the time to really listen. Their approach to wellness is a refreshing change from the typical doctor office experience.
Hormone Therapy Treatments
Hormone Therapy
At Millennia Wellness MD, we offer advanced hormone replacement therapy with bioidentical hormones to restore balance and improve quality of life for both men and women. Structurally identical to the hormones your body produces naturally, they ensure a more natural and effective treatment.
Bioidentical Hormone Replacement
Bioidentical hormones structurally identical to those your body produces naturally, restoring balance and improving quality of life for both men and women.
Women's Hormone Therapy
Relieve symptoms of menopause, perimenopause, and hormonal imbalance with bioidentical estrogen pellets and testosterone injections tailored to you.
Testosterone Replacement Therapy
Restore youthful testosterone levels for increased energy, improved muscle mass, and enhanced mental clarity — under expert medical supervision.
Men's Hormone Therapy
Comprehensive hormone optimization designed for men, addressing fatigue, low drive, and metabolic concerns with personalized protocols.

Weight Loss Treatments
Enhance Your Look
At Millennia Wellness MD, we help patients in our weight loss clinic in Frisco achieve and maintain their ideal weight through personalized, medically guided programs. We offer advanced medical weight loss therapies such as GLP-1, appetite suppressants, hormone-based diets, and lipotropic vitamin injections.
Each program is tailored to your unique needs, ensuring the most appropriate and effective treatment plan for sustainable weight loss. Our approach also includes comprehensive nutrition coaching and regular monthly follow-up appointments with Dr. Biju Mathew.


Weight Loss Testimonials
"I highly recommend Millennia Wellness MD. They helped me lose 50 lbs, and supported my wellness through supplements/shots. They make you feel like a lifelong friend on each visit. Thank you Dr. Biju and Vicky!"
"With consistency and the support of the Millennia Wellness team, I lost 20 pounds over six months. This isn't just a quick fix — it's a lifestyle change. I now feel more confident, strong, and in control of my health."
"Great practice! Dr. Mathew takes the time to really listen. Their approach to wellness is a refreshing change from the typical doctor office experience. Facility is nice and well-run. Highly recommend."
Cosmetic Treatments
Rejuvenate in our aesthetic space
Laser Treatments
Our Candela GentleMax Pro Plus® system provides effective laser treatments for hair removal, skin resurfacing, and vein treatment — safe, precise, and long-lasting results.
- • Cynosure Ultra Laser
- • Laser Hair Removal
- • Wrinkle Reduction
- • Acne Scar Treatment
- • Spider Vein Treatment
Neuromodulators
BOTOX® and other neuromodulators temporarily relax facial muscles, reducing dynamic wrinkles like forehead lines, frown lines, and crow's feet for a refreshed look.
NeuromodulatorsDermal Fillers
JUVÉDERM®, Restylane®, Belotero, Radiesse, and RHA restore volume, smooth wrinkles, and enhance facial contours with natural-looking results and minimal downtime.
DermalMicroneedling
Using the Candela Exceed™ pen, we stimulate collagen production to reduce fine lines, wrinkles, scars, and large pores for a smoother, radiant complexion.
MicroneedlingRF Microneedling
Candela Matrix™ combines microneedling with radiofrequency energy to tighten and lift skin, reduce wrinkles, and improve texture and tone.
RFMore Aesthetic Services
Sculptra®, Liquid BBL, Liquid Rhinoplasty, PDO Threads, Growth Factors, and HydroDermabrasion — a full suite of advanced aesthetic treatments.
- • Neuromodulators (BOTOX®, Dysport®, Daxxify)
- • Dermal Fillers (JUVÉDERM®, Restylane®, RHA®)
- • Sculptra®
- • Liquid BBL
- • Liquid Rhinoplasty
Wellness
Whole-body wellness, inside & out
Wound Care
Advanced wound care for diabetic foot ulcers, venous wounds, infections, and pressure sores — restoring tissue health and preventing recurrence.
Learn MoreIV Therapy
Nutrient-rich drips — Myer's Cocktail, Immune Drip, and Beauty Drip — deliver essential vitamins and minerals for maximum absorption and rapid revitalization.
Learn MoreHair Restoration
Non-surgical hair restoration using microneedling with AnteAGE MD exosomes to rejuvenate the scalp and reactivate dormant follicles.
Learn MoreVitamin Injections
B12, Vitamin D, Lipo Stat, Glutathione, and Myers Cocktail injections for energy, immunity, and metabolic support — no digestion required.
Learn MoreReviews
Hear from patients at our med spa in Frisco
"I still love Millennia Wellness and now there's even more to love. I had a HydroDiamond facial from Brittany and it was just what my face needed. Dr. Mathew and his staff are so supportive and kind. I wouldn't go anywhere else!"
"I was recovering from the flu and needed to get my energy back. I tried the Meyer's Cocktail hydration IV and WOW! I felt so much better the next day. If you're questioning trying an IV, give it a chance."
"I had such a great experience with Vicky and the Millennia Wellness team! This was my first time ever doing Laser Hair Removal and Vicky was so patient with me. I definitely plan to return in the future!"
"I am so glad I decided to take a chance and started going here. Dr. Mathew is the first doctor I've seen to actually listen. I've been going for three months and I've lost 30 lbs and addressed my vitamin deficiencies."
"I was feeling off after having a baby and wanted to get my hormones checked. Dr. Mathew was very professional and after my blood work was done he recommended a suitable treatment. I'm excited about the results."
"The Millennia team is so professional, welcoming, and kind! Dr. Mathew gave me a comprehensive breakdown of my lab results and I walked away with solutions to balance my gut health. Beautiful facility!"
"I've visited Millennia Wellness twice now, and I am absolutely thrilled with the results. From the moment I walked in, the staff made me feel incredibly welcome and comfortable. Genuine care throughout!"
"I've been coming here for my hormone treatments and I'm feeling GREAT! The moment you walk in the doors you are greeted with a friendly smile. The Dr. and staff are so informative, professional and welcoming."
"Can't say enough about how much Millennia Wellness MD has helped me. Their integrative approach to wellness has made a real difference in my health. I'm incredibly grateful for their expertise and compassion."
Contact Millennia Wellness MD
Take the next step on the journey to your best self
At Millennia Wellness MD, our med spa and weight loss clinic in Frisco is dedicated to helping you look, feel, and live your best through personalized advanced aesthetics and wellness care. Schedule your consultation today and start your journey toward a healthier, more vibrant you.
